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pandora bracelets These data offer additional evidence that the underlying causes of cerebral palsy extend beyond the clinical management of delivery.IntroductionCerebral palsy is the most common cause of physical disability in children, affecting approximately two in 1000 live births.1 Cerebral palsy comprises several more or less distinct subtypes with a wide spectrum of severity of motor disability, often accompanied by visual impairment, intellectual deficit, or epilepsy.2 A diagnosis cannot be reliably made until the age of at least 2 years,3 sometimes not until several years later for milder cases.4Cerebral palsy originates from damage to the immature brain https://www.pandoracharm2013.ca/, the causes of which are still largely unknown. However, several risk factors in pregnancy and the perinatal period have been identified, among them preterm delivery, multiple fetuses, atypical intrauterine growth, intrauterine exposure to infection, placental pathology, congenital malformations, birth asphyxia, perinatal infection, and perinatal stroke.5 6 7 8 Previous studies have recognised a possible heritable component of cerebral palsy. The condition recurs more than expected among twins,9 10 11 as well as among siblings in general,12 13 14 15 and an excess risk of cerebral palsy in children with a parent or other family member affected by the condition has been reported.15 16 Several candidate genes or single nucleotide polymorphisms have been investigated to explain familial clustering of cerebral palsy,17 18 with extensions to interactions with clinical factors and other genes,19 although positive findings have proved hard to replicate.We used data from a large population based cohort to systematically investigate recurrence of cerebral palsy among twins and first, second, and third degree relatives and thus to shed light on patterns of inheritance.MethodsData sourcesThe Central Population Registry of Norway was established in 1964 and was based on the national census of 1960.20 The registry assigns a unique 11 digit national identification number to each resident, together with a link to the parents’ identification numbers pandora bracelets.